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PARTHENON THERAPEUTICS is discovering and developing novel anti-cancer medicines that are designed to reprogram the tumor microenvironment. Many cancers create immune exclusion barriers that prevent the immune system from attacking tumors. The Parthenon approach to overcoming these barriers is to modulate the interplay among cancer cells, stromal cells, and immune cells.

Our lead program, PRTH-101, is a first-in-class humanized monoclonal antibody that blocks the interaction of Discoidin Domain Receptor 1 (DDR1) with collagen, thereby "punching holes" in the extracellular matrix barrier created by the tumor. With the extracellular matrix barrier breached, immune cells are able to infiltrate and attack the tumor. PRTH-101 is poised to enter Phase 1 clinical trials.

PRTH-101 is followed by a pipeline of preclinical projects targeting orthogonal components of the tumor microenvironment that promote immune exclusion.

Parthenon combines its drug discovery and development efforts with a precision oncology approach to get the right medicines to the right patients. We use proprietary AI technology to digitally deconstruct the TME and develop unique insights to enable biomarker-driven patient selection strategies designed to guide clinical applications.

Parthenon is led by an experienced leadership team with extensive drug development experience and is backed by world-class investors.

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We are seeking self-motivated individuals who desire to have a direct impact on the science within our early stage, fast-paced, and dynamic biotech. The candidates will have extensive hands-on experience in developing and performing molecular and cellular tumor biology assays and an abiding interest in drug discovery. The associate scientists in these positions are expected to establish state-of-the-art in vitro assays and ex vivo and in vivo models to validate therapeutic targets, demonstrate efficacy of lead candidates, and perform detailed mechanism of action studies internally and with external partners. They will have the opportunity to design and execute non-routine experiments with a high level of autonomy and minimal supervision, with the potential for advancement into project leadership roles.

Role & Responsibilities:
  • Culture and engineer cells for in vitro and in vivo studies.
  • Isolate primary cells from human and mouse blood.
  • Perform and design various in vitro experiments with human and mouse cells to discover therapeutic antibody drug candidates and uncover novel insights into target biology underlying the mechanisms of immune exclusion. Relevant assays include, but not limited to:
    • Protein and cell-based binding and functional assays, including flow cytometry and reporter cell assays.
    • Evaluate cellular biomarkers using a variety of state-of-the-art methods (e.g., immunofluorescence, live-cell imaging, qRT-PCR, ELISAs, HTRF and alphaLISA, MSD, Westerns, etc).
    • Evaluate cellular phenotypic endpoints using various growth, migration, and morphology assays.
  • Support in vivo studies.
  • Analyze and present data using FlowJo, Excel, and Prism in professional 'publication ready' format. Properly record and document results in a timely fashion.
  • Demonstrate clear and professional verbal and written communication.
  • Collaborate closely with other teams within the organization.

Job Qualifications
    • B.S/B.A in life sciences (immunology preferred, oncology, cell biology, or a related discipline) with 3 years laboratory research experience minimum. Industry experience is preferred.
    • Proficiency with flow cytometry and cell culture is a must.
    • Willingness to perform in vivo study is a must. Experience with in vivo studies preferred, including handling mice, collecting and processing tissues.
    • Extensive experience with cell engineering and cell-based function assays (e.g., CRISPR/siRNA, transient and stable transfection of mammalian cell lines, reporter cell assays, T cell killing assay, live-cell imaging).
    • Experience with routine molecular biology techniques and cell-based assays (e.g., qRT-PCR, Western blotting, ELISA, immunofluorescence).
    • Ability to thrive in fast paced environment.
    • Strong organizational and communication skills.
    • Demonstrated ability to design and execute experiments, interpret results, effectively troubleshoot as needed, and properly record experimental data in an electronic laboratory notebook in a highly organized manner

    Contact to apply.

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