We are seeking self-motivated individuals who desire to have a direct impact on the science within our early stage, fast-paced, and dynamic biotech. The candidates will have extensive hands-on experience in developing and performing molecular and cellular tumor biology assays and an abiding interest in drug discovery. The associate scientists in these positions are expected to establish state-of-the-art biochemical and cellular assays and ex vivo and in vivo models to validate therapeutic targets, demonstrate efficacy of lead compounds, and perform detailed mechanism of action studies internally and with external partners. They will have the opportunity to design and execute non-routine experiments with a high level of autonomy and minimal supervision, with the potential for advancement into project leadership roles. Role & Responsibilities:
- Perform various in vitro experiments with human and mouse cells to discovery therapeutic antibody drug candidates and uncover novel insights into target biology underlying the mechanisms of immune exclusion.
- Relevant assays include, but not limited to:
- Protein and cell-based binding and functional assays, including flow cytometry and reporter cell assays.
- Engineering of cell lines using CRISPR and maintaining them in tissue culture.
- Processing of human blood and primary cell isolation.
- Evaluate cellular biomarkers using a variety of state-of-the-art methods (e.g., Westerns, immunofluorescence, qRT-PCR, ELISAs, HTRF and alphaLISA, MSD, etc).
- Evaluate cellular phenotypic endpoints using various growth, migration, and morphology assays
- Analyze and present data in professional 'publication ready' format. Properly record and document results in a timely fashion.
- Demonstrate clear and professional verbal and written communication.
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- At least 4 years of full-time experience working in a biology lab, with industry experience being preferable.
- Experience with routine molecular biology techniques (e.g., qRT-PCR, Western blotting, ELISA, immunofluorescence).
- Extensive expertise with tissue culture and cell-based assays (e.g., CRISPR/siRNA, transient and stable transfection of mammalian cell lines, reporter cell assays, flow cytometry).
- Experience with in vivo studies preferred, including handling mice, collecting and processing tissues.
- Ability to thrive in fast paced environment.
- Strong organizational and communication skills.
- Demonstrated ability to design and execute experiments, interpret results, effectively troubleshoot as needed, and properly record experimental data in an electronic laboratory notebook in a highly organized manner.